TOPLEXIL SYRUP 150ML

Toplexil is indicated to soothe dry coughs and irritative coughs in adults and children over 2 years of age, particularly when they occur in the evening or at night.
TOPLEXIL SYRUP 150ML
Important to know about Toplexil Syrup ?
It is recommended to calm dry coughs and irritation coughs in adults and children over 2 years of age, especially when they occur in the evening or at night.
Toplexil Syrup Uses, Dosage, Side Effects, Precautions
what is toplexil Syrup used for and indication?
Symptomatic treatment of troublesome nonproductive coughs, especially at night.
Toplexil Syrup Dosage
RESERVED FOR ADULTS AND CHILDREN OVER 2 YEARS.
toplexil dosage for adults
10 ml per dose, 4 times a day.
Pediatric population
toplexil dosage for children
the daily dosage depends on the weight of the child (1 ml of syrup per kg of body weight per day), which is indicative:
Child from 13 to 20 kg (ie 2 to 6 years): 5 ml per dose, 2 to 3 times a day,
Child from 20 to 30 kg (6 to 10 years): 10 ml per dose, 2 to 3 times a day,
Child from 30 to 40 kg (10 to 12 years): 10 ml per dose, 3 to 4 times a day
Child over 40 kg (12 years old): 10 ml per dose, 4 times a day.
The catches are to be renewed when necessary and spaced at least 4 hours apart.
Administration mode
Oral way.
 Use the measuring cup.
Evening intake should be favored because of the sedative effect, especially at the beginning of treatment, of oxomemazine.
Contraindications
Oxomemazine hypersensitivity
Infant less than 2 years old
History of agranulocytosis
Urethroprostatic disorders at risk of urinary retention
Risk of narrow-angle glaucoma
Sun exposure
Fructose intolerance
Glucose galactose malabsorption syndrome
Sucrase / isomaltase deficiency
Alcohol consumption
Pregnancy 1st trimester
Feeding with milk
This drug is CONTRAINDICATED in the following cases:
Hypersensitivity to any component, including antihistamines,
Due to the presence of oxomemazine
 infant (less than 2 years) (see section Warnings and precautions for use),
history of agranulocytosis,
risk of urinary retention linked to urethro-prostatic disorders,
risk of glaucoma by closing the angle,
In association with cabergoline and quinagolide (see Interactions with other drugs and other forms of interaction).
How it works Toplexil Syrup
Pharmacotherapeutic group: ANTIHISTAMINE FOR SYSTEMIC USE, ATC code: R06AD08 (R: Respiratory system).
Oxomemazine : antihistamine H1, phenothiazine with aliphatic side chain, which is characterized by:
A marked sedative effect at the usual doses, of histaminergic and central adrenolytic origin,
 An anticholinergic effect causing peripheral adverse effects,
A peripheral adrenolytic effect, which may have a hemodynamic effect (risk of orthostatic hypotension).
Antihistamines have in common the property of opposing, by more or less reversible competitive antagonism, the effects of histamine especially on the skin, the bronchi, the intestine, and the vessels.
Toplexil Syrup Side Effects
The pharmacological characteristics of the oxomemazine molecule cause undesirable effects of unequal intensity and linked or not to dose (see section Pharmacodynamic properties ):
· Neurovegetative effects:
 sedation or drowsiness, more marked at the beginning of treatment;
 anticholinergic effects such as dryness of the mucous membranes, constipation, accommodation disorders, mydriasis, heart palpitations, risk of urinary retention;
orthostatic hypotension;
balance disorders, dizziness, memory loss or concentration (more common in the elderly);
motor incoordination, tremors;
mental confusion, hallucinations;
more rarely, effects like excitation: agitation, nervousness, insomnia.
· Awareness Reactions:
erythema, eczema, pruritus, purpura, possibly giant urticaria,
edema, more rarely angioedema,
anaphylactic shock,
photosensitization;
· Hematological disorders:
leukopenia, neutropenia, exceptional agranulocytosis ;
thrombocytopenia,
Hemolytic anemia.
Due to the presence of glycerol, risk of digestive disorders and diarrhea.
Toplexil Syrup Interactions
Drugs lowering the epileptogenic threshold :
The joint use of proconvulsant drugs, or lowering the epileptogenic threshold, should be carefully weighed, because of the severity of the risk involved. These drugs are represented by most antidepressants (imipramines, selective serotonin reuptake inhibitors), neuroleptics (phenothiazines and butyrophenones), mefloquine, chloroquine, bupropion, tramadol.
Atropine drugs :
It must be taken into account that atropine substances can add their adverse effects and more easily result in urinary retention, acute glaucoma, constipation, dryness of the mouth, etc.
The various atropine drugs are represented by imipramine antidepressants, most atropine H1 antihistamines, antiparkinsonian anticholinergics, atropine antispasmodics, disopyramide, phenothiazine neuroleptics and clozapine.
Sedative drugs :
It must be taken into account that many drugs or substances can add their depressant effects of the central nervous system and help reduce alertness.
These are morphine derivatives (analgesics, antitussives and substitution treatments), neuroleptics, barbiturates, benzodiazepines, anxiolytics other than benzodiazepines (eg meprobamate), hypnotics, sedative antidepressants (amitriptyline, doxepin , mianserine, mirtazapine, trimipramine), sedative H1 antihistamines, central antihypertensives, baclofen and thalidomide.
Associations contraindicated :
· Dopaminergics, excluding Parkinson’s (cabergoline, quinagolide): Reciprocal antagonism of the dopaminergic agonist and neuroleptics.
Associations advised against :
·Other sedative drugs  : Potentiation of the sedative effect of H1 antihistamines.
·Alcohol consumption  : Alcohol enhancement of the sedative effect of these substances. Impairment of alertness can make driving and using machines dangerous. Avoid taking alcoholic drinks and drugs containing alcohol.
Associations subject to precautions for use :
·Gastrointestinal topicals, antacids and anthrax  : Decreased digestive absorption of phenothiazine neuroleptics. Take gastrointestinal topicals and antacids away from phenothiazinic neuroleptics (more than 2 hours, if possible).
Associations to consider :
·Antihypertensive drugs  : Increase the risk of hypotension, including orthostatic.
·Beta-blockers (except esmolol and sotalol)  : Vasodilator effect and risk of hypotension, especially orthostatic (additive effect).
·Beta-blockers in heart failure (bisoprolol, carved idol, metoprolol, nebivolol ): Vasodilator effect and risk of hypotension, particularly orthostatic (additive effect).
·Nitrate and related derivatives  : Increased risk of hypotension, especially orthostatic.